The Effects of Chronic Depression and Inflammation on Incident Type 2 Diabetes Mellitus in men
P.J. Tully1,2, G.A. Wittert1
1The University of Adelaide, School of Medicine, Discipline of Medicine, Freemasons Foundation Centre for Men’s Health, Australia
2University of Freiburg, Institute of Psychology, Department of Rehabilitation Psychology and Psychotherapy, Germany
Background: Inflammation is a possible aetiological mechanism through which depression increases incident diabetes risk however there are few longitudinal studies. Methods: A cohort of 1,110 men aged 35 years or older underwent venous withdrawal for cardiometabolic risk factors, IL-6, CRP, and e-selectin at baseline and 5 year follow-up. Depression symptoms were assessed by CES-D or BDI-I, respondents were categorized into chronic or remitting depression. Logistic regression determined whether diabetes mellitus was associated with depression chronicity, inflammation, ? inflammation, and their interaction terms. Findings: There were 158 cases of incident diabetes (14.2%). The chronic depression and ? IL-6 interaction term was associated with greater diabetes risk (OR 2.36; 95% CI 1.28 – 4.36, p =.006). Chronic depression and ? e-selectin interaction term also significantly increased diabetes risk (OR 1.08; 95% CI 1.00 – 1.16, p =.05). Conclusions: These data provide support for inflammation as a biological mechanisms through which chronic depression increases diabetes risk.